Hematotoxic Snakebite Victim with Trauma: The Role of Guided Transfusion, Rotational Thromboelastometry, and Tranexamic Acid

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Tranexamic acid and trauma-induced coagulopathy

Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly used for reduction of blood loss in perioperative situations, while recently it has attracted attention for clinical use in the trauma field. In 2010, the Clinical Randomization of an Anti...

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Trauma Pharmacology: Early Administration of Tranexamic Acid

Early hospital management of trauma patients is a daily activity for most emergency physicians. The ability to quickly assess, stabilize and initiate treatment of these patients is critically important to optimize outcomes. This issue of “Resident Journal Review” focuses on selected updates in the trauma literature. We specifically review new developments in trauma pharmacology, biomarkers in t...

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Tranexamic acid administration to pediatric trauma patients in a combat setting: the pediatric trauma and tranexamic acid study (PED-TRAX).

BACKGROUND Early administration of tranexamic acid (TXA) has been associated with a reduction in mortality and blood product requirements in severely injured adults. It has also shown significantly reduced blood loss and transfusion requirements in major elective pediatric surgery, but no published data have examined the use of TXA in pediatric trauma. METHODS This is a retrospective review o...

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Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe trauma.

BACKGROUND We investigated whether hyperfibrinolysis and its severity was associated with outcome of traumatized and nontraumatized patients. METHODS From April 2008 to April 2010, all emergency patients with hyperfibrinolysis were enrolled in this study. Hyperfibrinolysis patients were divided into traumatized (trauma hyperfibrinolysis group) and nontraumatized (nontrauma hyperfibrinolysis g...

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ژورنال

عنوان ژورنال: Wilderness & Environmental Medicine

سال: 2020

ISSN: 1080-6032

DOI: 10.1016/j.wem.2020.08.003